Description

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JWH-018 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with some selectivity for CB₂. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as “incense blends”.

As a full agonist at both the CB₁ and CB₂ cannabinoid receptors, this chemical compound is classified as an analgesic medication. The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis.

These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling. As the cause is poorly understood in chronic pain states, more research and development must be done before the therapeutic potential of this class of biologic compounds can be realized.

Usage

At least one case of JWH dependence has been reported by the media.The user consumed it daily for eight months. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence. It has been shown to cause profound changes in CB₁ receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids

On October 15, 2011, Anderson County coroner Greg Shore attributed the death of a South Carolina college basketball player to “drug toxicity and organ failure” caused by JWH-018. An November 2011 email concerning the case was released in December 2011 under the Freedom of Information Act after multiple requests to see the information had been denied.

Compared to THC, which is a partial agonist at CB receptors, JWH-018, and many synthetic cannabinoids, are full agonists. THC has been shown to inhibit GABA receptor neurotransmission in the brain via several pathways.

JWH-018 may cause intense anxiety, agitation, and, in rare cases (generally with non-regular JWH users), has been assumed to have been the cause of seizures and convulsions by inhibiting GABA neurotransmission more effectively than THC. Cannabinoid receptor full agonists may present serious dangers to the user when used to excess.

Various physical and psychological adverse effects have been reported from JWH-018 use. One study reported psychotic relapses and anxiety symptoms in well-treated patients with mental illness following JWH-018 inhalation.Due to concerns about the potential of JWH-018 and other synthetic cannabinoids to cause psychosis in vulnerable individuals, it has been recommended that people with risk factors for psychotic illnesses (like a past or family history of psychosis) not use these substances.

Side Effects of Smoking JWH-018

JWH-018 mimics the mechanism of THC found in marijuana, thus affecting the functions of the brain resulting in CNS depression. Since it binds itself to CB1 receptors dominantly found in the brain, expect to notice symptoms of alterations in the control of emotions, motivation, judgment, memory, and learning. For smoking a regular dose of 3 to 5mg of JWH-018, its psychological effects include:

• • Heightened mood
  • Enhanced sense of humor
  • Heightened curiosity and intrigue
  • Racing thoughts
  • Time distortion and dilation
  • Buzzing or humming like a psychedelic experience
  • Reduced concentration
  • Relaxed state
  • Mild euphoria (phasing in between bouts)
  • Manic-depressive disorder

Users who suddenly withdraw from using JWH-018 may experience:

• Tremors
• Nausea and vomiting
• Diarrhea
• Bouts of headaches
• Insomnia
• Heart palpitations
• Restlessness